14. September 2016
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BTB-Conversion™ Technology
The BTB-Conversion™ approach
Eight years of advanced biomaterial research and translational development at the University and ETH Zurich, in collaboration with leading Swiss surgeons, have led to ZuriMED’s Bone-Tendon-Bone(BTB)-Conversion™ Technologies for knee ligament reconstruction.
BTB-Conversion™ Technology
The BTB-Conversion™ approach
Eight years of advanced biomaterial research and translational development at the University and ETH Zurich, in collaboration with leading Swiss surgeons, has led to ZuriMED’s Bone-Tendon-Bone(BTB)-Conversion™ Technologies for knee ligament reconstruction.
Standard options for Anterior
Cruciate Ligament (ACL) Reconstruction
Option I: Hamstring Tendon Graft
The hamstring grafting approach is less painful, but with lower performance attributable to slower healing and higher risk of pull-out.
Option II: Bone-Tendon-Bone (BTB) Graft
A BTB graft offers higher performance with faster healing and improved strength, but at the cost of potentially severe pain at the graft extraction site.
All existing clinical approaches represent a forced choice between postoperative pain at the graft source and mechanical stability of the reconstruction.
Our Solution
Our BTB-Conversion-Kit™ is able to harness the advantages of existing approaches while avoiding their disadvantages. Over five years of translational research and development in collaboration with leading Swiss orthopaedic surgeons has culminated in what we expect will be a revolutionary device for ACL reconstruction. The BTB-Conversion-Kit™ relies on a novel combination of advanced biomaterials to dramatically accelerate graft healing, while minimizing postoperative pain and time for recovery.
BTB-Conversion-Kit™
Faster healing, less pain
The BTB-Conversion-Kit™ contains two identical BTB-Converter™ elements, each featuring patented innovations that make the devices osteoconductive (promoting bone healing) and fully bioresorbable. The BTB-Converter™ effectively upgrades a less painful hamstring graft (or any other flexible graft material) into a higher performance BTB-like graft, with accelerated graft to bone attachment.
The device requires no special instrumentation or additional surgical training, facilitating its adoption in the operating room. The potential benefits for the patient are immediately recognizable to the surgeon and patient.
We expect that the potential benefits with our BTB-Conversion-Kit™ are:
* Pain-related complications for a hamstring graft have been reported to be one third compared to standard BTB grafts. Kautzner, et. al., International Orthopaedics 2014
** Revision rates after 5 years for BTB grafts are 33% lower compared to standard hamstring grafts. Gifstad, et. al., The American Journal of Sports Medicine 2014; Registry study based on 45,998 patients
Extracortical fixation technology
The single strand VariLoop™ for superior ligament fixation
Simple, easy to use, self flipping – truly knotless. Highly reliable and strong in all testing conditions. This implant can be used in different configurations in many indications where tension or compression is key for healing.
MagicBox™ for rapid button assembly onto open sutures
The first knotless button that can be intraoperatively mounted with ease. This technology opens the door to many new approaches where stitching a cortical fixation device to a tendon end was previously not possible.
MagicBox™ for rapid button assembly onto open sutures
The first knotless button that can be intraoperatively mounted with ease. This technology opens the door to many new approaches where stitching a cortical fixation device to a tendon end was previously not possible.
The single strand VariLoop™ for superior ligament fixation
Simple, easy to use, self flipping – truly knotless. Highly reliable and strong in all testing conditions. This implant can be used in different configurations for various indications where tension or compression is key for healing.
About ZuriMED Technologies AG
Innovation, translational development and back to the patient
ZuriMED Technologies AG is an innovation-driven Swiss company based in Zurich that spun-off from the Laboratory for Orthopaedic Biomechanics, Departments of Health Science & Technology at the ETH Zürich and the Department of Orthopaedics at the University of Zurich in 2015. ZuriMED Technologies develops smart solutions for novel treatments in sports medicine.
Embedded between a Swiss leading orthopaedic hospital and a Swiss research centre of national importance
The company’s offices are co-located within a translational musculoskeletal research centre known as the “Balgrist Campus”. Access to the research facilities of Balgrist Campus enables ZuriMED a full spectrum of professional testing of prototypes during all stages of product development: animal and human cadaver labs, mechanical testing machines, modern imaging modalities (µCT, CTs, 7-T MRI) and close feedback from surgeons, scrub nurses and other healthcare professionals.
History
Timeline
2020
ZuriMED closes a license deal with an international medical device company
One of ZuriMED’s endocortical fixation technologies for soft tissue repair has been licensed to an international medical device company. A strategic partnership has been established to work together to bring this technology to clinical applications.
2019
ZuriMED obtains the Innosuisse Certificate
The company has now obtained the Innosuisse certificate in recognition for the potential of its technology and solutions. The role of Innosuisse – the Swiss Innovation Agency – is to promote science-based innovation in the interests of industry and society in Switzerland.
2018
Capital increase – loan conversion executed
Loan conversion of the seed round investment into equity.
2017
Start of Innosuisse funded First-in-man study
Clinical trial on ZuriMED’s fist product, the BTB-Converter™ was approved by Swissethics and sponsored by Innosuisse (formerly Commission for Technology and Innovation in Switzerland [CTI]).
2016
Seed round investment received
Investment in terms of convertible loan. ZuriMED moves into the newly opened Balgrist Campus.
2015
Incorporation of ZuriMED Technologies AG
Winner of Venture Kick Final, Switzerland’s largest start-up acceleration program. Presenting 2nd best business plan by >>venture>>, the leading competition for entrepreneurs in Switzerland, a joint initiative of ETH Zürich, McKinsey & Company, Knecht Holding, Innosuisse and EPFL.
2013
Proof of concept
Production of functional prototypes by external industry partners. First collection of pre-clinical data and proof of the concept by the researchers. Initiation of technology transfer by the founders’ team, a spinoff from the Laboratory for Orthopaedic Biomechanics at the University and ETH Zurich.
News
23. March 2016
ZuriMED selected for GoGermany 2016
Das Startup-Unternehmen ZuriMed ertreibt ein neues Transplantat unter dem Namen «Bone-Tendon-Bone» für die Rekonstruktion des…
10. September 2015
ZuriMED Team won the Venture Kick final
The future of birth control and a novel knee ligament reconstruction method win the Venture…
Acknowledgements
Disclaimer
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